Authors (including presenting author) :
Lo WT(1), Yu PH(1), Chan HY(1)
Affiliation :
(1)X-ray Department, Our Lady of Maryknoll Hospital
Introduction :
Primary hyperparathyroidism (PHPT) is known to increase fracture risk of its patients by increasing parathyroid hormone (PTH) secretion. High PTH level leads to a decrease in content of both cortical and trabecular bone through enhanced endocortical resorption, ultimately causing a decrease in bone mineral density (BMD), which is highly correlated to an increase in fracture risk. By using FRAX®, a fracture risk assessment tool in predicting 10-year probability hip fracture , risk of hip fracture caused by PHPT can be predicted.
Objectives :
To compare the L-spine BMD and FRAX score of the postmenstrual Chinese female patients with hyperparathyroidism with normal patients.
Methodology :
Questionnaires with information including age, gender, history of fracture, medication and treatment, smoking and alcohol habits were collected from DEXA patients. L-spine BMD and femoral neck BMD were obtained from the DEXA scan. The collected data was then input in the FRAX calculator. Target patients with hyperparathyroidism were set as the experimental group, while the normal patients were set as the control group.
Result & Outcome :
In 2020, the L-spine BMD and FRAX score of subjects with hyperparathyroidism were lower than that of the normal subjects (unpaired t-test).
