Number of patients with amputation is expected to be doubled by 2050. Traditional prosthesis is limited in its use by the frequent problems related to the socket-stump interface. Osseointegration is implantation of endoprosthesis into stump bone and connection to prosthesis with a connector. It is a viable option with many biological and biomechanical advantages. It has better fit, no skin problem, no interface movement. It allows better biomechanics, better joint range of movement, and provides perception on ground contact. This improves the quality of life of patient with amputation. The recognized risks and complications of osseointegration include infection, the need of stoma care, and potential peri-prosthetic fracture. The process of osseointegration requires a careful protocol starting from pre-operative assessment and selection of patient, the surgical procedure, early postoperative care, and rehabilitation. The benefits of osseointegration has been reported in international journals since it is started in 1990. It is expected osseointegration will be a viable mobility solution for an increasing spectrum of patient with amputation in the future.
