The Covid-19 pandemic which commenced in December 2019 has resulted in more than 1.36 million confirmed cases, 2.9 million deaths and affected 192 countries. This pandemic of the century has once again reminded us the importance of infection control measures, research in the development of antiviral and vaccine against the emerging infectious diseases, but even more important, to respect the wild life in the nature. Various institutes, governments and pharmaceuticals have worked together to develop effective Covid-19 antivirals and vaccines. In Hong Kong, the tight infection control measures and the early quarantine of confirmed patients allow us to commence early treatment in high risk patients, thus optimizing the effect of the antiviral treatment. This resulted in effective suppression of patient’s viral load, hastened clinical recovery and reduced risk of deterioration. In this lecture, I will discuss the various treatment modalities in Covid-19 infection.